Phosphorylation of DGCR8 Increases Its Intracellular Stability and Induces a Progrowth miRNA Profile

During miRNA biogenesis, the microprocessor complex (MC), which is composed minimally of Drosha, an RNase III enzyme, and DGCR8, a double-stranded RNA-binding protein, cleaves the primary miRNA (pri-miRNA) in order to release the pre-miRNA stem-loop structure. Using phosphoproteomics, we mapped 23 p...

Descripción completa

Detalles Bibliográficos
Autores principales: Herbert, Kristina M., Pimienta, Genaro, DeGregorio, Suzanne J., Alexandrov, Andrei, Steitz, Joan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892995/
https://www.ncbi.nlm.nih.gov/pubmed/24239349
http://dx.doi.org/10.1016/j.celrep.2013.10.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892995/
https://www.ncbi.nlm.nih.gov/pubmed/24239349
http://dx.doi.org/10.1016/j.celrep.2013.10.017

Ejemplares similares