Midline crossing and Slit responsiveness of commissural axons require USP33

Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain to be elucidated. Here we report that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 is essential for midline crossing by commissural axon...

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Autores principales: Yuasa-Kawada, Junichi, Kinoshita-Kawada, Mariko, Wu, Guan, Rao, Yi, Wu, Jane Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893063/
https://www.ncbi.nlm.nih.gov/pubmed/19684588
http://dx.doi.org/10.1038/nn.2382
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author Yuasa-Kawada, Junichi
Kinoshita-Kawada, Mariko
Wu, Guan
Rao, Yi
Wu, Jane Y.
author_facet Yuasa-Kawada, Junichi
Kinoshita-Kawada, Mariko
Wu, Guan
Rao, Yi
Wu, Jane Y.
author_sort Yuasa-Kawada, Junichi
collection PubMed
description Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain to be elucidated. Here we report that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 is essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role of USP33 in vertebrate commissural axon guidance and in Slit signaling.
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spelling pubmed-38930632014-01-15 Midline crossing and Slit responsiveness of commissural axons require USP33 Yuasa-Kawada, Junichi Kinoshita-Kawada, Mariko Wu, Guan Rao, Yi Wu, Jane Y. Nat Neurosci Article Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain to be elucidated. Here we report that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 is essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role of USP33 in vertebrate commissural axon guidance and in Slit signaling. 2009-08-16 2009-09 /pmc/articles/PMC3893063/ /pubmed/19684588 http://dx.doi.org/10.1038/nn.2382 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Yuasa-Kawada, Junichi
Kinoshita-Kawada, Mariko
Wu, Guan
Rao, Yi
Wu, Jane Y.
Midline crossing and Slit responsiveness of commissural axons require USP33
title Midline crossing and Slit responsiveness of commissural axons require USP33
title_full Midline crossing and Slit responsiveness of commissural axons require USP33
title_fullStr Midline crossing and Slit responsiveness of commissural axons require USP33
title_full_unstemmed Midline crossing and Slit responsiveness of commissural axons require USP33
title_short Midline crossing and Slit responsiveness of commissural axons require USP33
title_sort midline crossing and slit responsiveness of commissural axons require usp33
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893063/
https://www.ncbi.nlm.nih.gov/pubmed/19684588
http://dx.doi.org/10.1038/nn.2382
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