Inhibition of c-Kit Is Not Required for Reversal of Hyperglycemia by Imatinib in NOD Mice

(1) AIM/HYPOTHESIS: Recent studies indicate that tyrosine kinase inhibitors, including imatinib, can reverse hyperglycemia in non-obese diabetic (NOD) mice, a model of type 1 diabetes (T1D). Imatinib inhibits c-Abl, c-Kit, and PDGFRs. Next-generation tyrosine kinase inhibitors for T1D treatment shou...

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Detalles Bibliográficos
Autores principales: Lau, Janet, Zhou, Qiang, Sutton, Susan E., Herman, Ann E., Schmedt, Christian, Glynne, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893161/
https://www.ncbi.nlm.nih.gov/pubmed/24454763
http://dx.doi.org/10.1371/journal.pone.0084900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893161/
https://www.ncbi.nlm.nih.gov/pubmed/24454763
http://dx.doi.org/10.1371/journal.pone.0084900

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