A Simple Lattice Model That Captures Protein Folding, Aggregation and Amyloid Formation

The ability of many proteins to convert from their functional soluble state to amyloid fibrils can be attributed to inter-molecular beta strand formation. Such amyloid formation is associated with neurodegenerative disorders like Alzheimer's and Parkinson's. Molecular modelling can play a...

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Detalles Bibliográficos
Autores principales: Abeln, Sanne, Vendruscolo, Michele, Dobson, Christopher M., Frenkel, Daan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893179/
https://www.ncbi.nlm.nih.gov/pubmed/24454816
http://dx.doi.org/10.1371/journal.pone.0085185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893179/
https://www.ncbi.nlm.nih.gov/pubmed/24454816
http://dx.doi.org/10.1371/journal.pone.0085185

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