Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations

The solution dynamics of antibodies are critical to antibody function. We explore the internal solution dynamics of antibody molecules through the combination of time-resolved fluorescence anisotropy experiments on IgG1 with more than two microseconds of all-atom molecular dynamics (MD) simulations...

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Detalles Bibliográficos
Autores principales: Kortkhonjia, Ekaterine, Brandman, Relly, Zhou, Joe Zhongxiang, Voelz, Vincent A., Chorny, Ilya, Kabakoff, Bruce, Patapoff, Thomas W., Dill, Ken A., Swartz, Trevor E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893241/
https://www.ncbi.nlm.nih.gov/pubmed/23396076
http://dx.doi.org/10.4161/mabs.23651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893241/
https://www.ncbi.nlm.nih.gov/pubmed/23396076
http://dx.doi.org/10.4161/mabs.23651

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