Metabolic Effects of Acute Thiamine Depletion Are Reversed by Rapamycin in Breast and Leukemia Cells

Thiamine-dependent enzymes (TDEs) control metabolic pathways that are frequently altered in cancer and therefore present cancer-relevant targets. We have previously shown that the recombinant enzyme thiaminase cleaves and depletes intracellular thiamine, has growth inhibitory activity against leukem...

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Detalles Bibliográficos
Autores principales: Liu, Shuqian, Miriyala, Sumitra, Keaton, Mignon A., Jordan, Craig T., Wiedl, Christina, Clair, Daret K. St., Moscow, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893258/
https://www.ncbi.nlm.nih.gov/pubmed/24454921
http://dx.doi.org/10.1371/journal.pone.0085702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893258/
https://www.ncbi.nlm.nih.gov/pubmed/24454921
http://dx.doi.org/10.1371/journal.pone.0085702

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