Cargando…

Metabolic Effects of Acute Thiamine Depletion Are Reversed by Rapamycin in Breast and Leukemia Cells

Thiamine-dependent enzymes (TDEs) control metabolic pathways that are frequently altered in cancer and therefore present cancer-relevant targets. We have previously shown that the recombinant enzyme thiaminase cleaves and depletes intracellular thiamine, has growth inhibitory activity against leukem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Shuqian, Miriyala, Sumitra, Keaton, Mignon A., Jordan, Craig T., Wiedl, Christina, Clair, Daret K. St., Moscow, Jeffrey A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893258/ https://www.ncbi.nlm.nih.gov/pubmed/24454921 http://dx.doi.org/10.1371/journal.pone.0085702

Ejemplares similares

Plasma TNF-α and Soluble TNF Receptor Levels after Doxorubicin with or without Co-Administration of Mesna—A Randomized, Cross-Over Clinical Study
por: Hayslip, John, et al.
Publicado: (2015)

Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect
por: Xu, Yong, et al.
Publicado: (2014)

p53 Regulates Oxidative Stress-Mediated Retrograde Signaling: A Novel Mechanism for Chemotherapy-Induced Cardiac Injury
por: Velez, Joyce M., et al.
Publicado: (2011)

Radioresistance in Prostate Cancer: Focus on the Interplay between NF-κB and SOD
por: Kumar, Sameera, et al.
Publicado: (2021)

Chemotherapy-Induced Tissue Injury: An Insight into the Role of Extracellular Vesicles-Mediated Oxidative Stress Responses
por: Yarana, Chontida, et al.
Publicado: (2017)

SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy
por: Sharma, Sudha, et al.
Publicado: (2020)

Inverse Relationship between PSA and IL-8 in Prostate Cancer: An Insight into a NF-κB-Mediated Mechanism
por: Xu, Yong, et al.
Publicado: (2012)

Extracellular Vesicles and Cancer Therapy: Insights into the Role of Oxidative Stress
por: Ho, Jenni, et al.
Publicado: (2022)

Severe lactic acidosis reversed by thiamine within 24 hours
por: Amrein, Karin, et al.
Publicado: (2011)

Thiamine Diphosphate in Whole Blood, Thiamine and Thiamine Monophosphate in Breast-Milk in a Refugee Population
por: Stuetz, Wolfgang, et al.
Publicado: (2012)

Reversal of severe lactic acidosis with thiamine in a renal allograft recipient
por: Kumar, K. Nanda, et al.
Publicado: (2015)

Thiamine mediated reversal of left ventricular dysfunction in patients with alcoholic cardiomyopathy
por: Satish, Oruganti Sai, et al.
Publicado: (2021)

Potent Radical-Scavenging Activities of Thiamin and Thiamin Diphosphate
por: Okai, Yasuji, et al.
Publicado: (2007)

Mammalian Target of Rapamycin Regulates Nox4-Mediated Podocyte Depletion in Diabetic Renal Injury
por: Eid, Assaad A., et al.
Publicado: (2013)

miR-17* Suppresses Tumorigenicity of Prostate Cancer by Inhibiting Mitochondrial Antioxidant Enzymes
por: Xu, Yong, et al.
Publicado: (2010)

Paraptosis Cell Death Induction by the Thiamine Analog Benfotiamine in Leukemia Cells
por: Sugimori, Naomi, et al.
Publicado: (2015)

Thiamine and selected thiamine antivitamins — biological activity and methods of synthesis
por: Tylicki, Adam, et al.
Publicado: (2018)

The genes and enzymes involved in the biosynthesis of thiamin and thiamin diphosphate in yeasts
por: Kowalska, Ewa, et al.
Publicado: (2008)

Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women
por: McCann, Adrian, et al.
Publicado: (2017)

Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity
por: Chan, Alex H. Y., et al.
Publicado: (2022)

PPARγ and Its Role in Cardiovascular Diseases
por: Chandra, Mini, et al.
Publicado: (2017)

A Redox-active Mn Porphyrin, MnTnBuOE-2-PyP(5+), Synergizes with Carboplatin in Treatment of Chemoresistant Ovarian Cell Line
por: Chaiswing, Luksana, et al.
Publicado: (2022)

Thiamine metabolism genes in diatoms are not regulated by thiamine despite the presence of predicted riboswitches
por: Llavero‐Pasquina, Marcel, et al.
Publicado: (2022)

Amorphization of Thiamine Mononitrate: A Study of Crystallization Inhibition and Chemical Stability of Thiamine in Thiamine Mononitrate Amorphous Solid Dispersions
por: Arioglu-Tuncil, Seda, et al.
Publicado: (2020)

Reduced Thiamine Availability and Hyperglycemia Impair Thiamine Transport in Renal Glomerular Cells through Modulation of Thiamine Transporter 2
por: Mazzeo, Aurora, et al.
Publicado: (2021)

Correction: Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity
por: Chan, Alex H. Y., et al.
Publicado: (2022)

Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues
por: Chan, Alex H. Y., et al.
Publicado: (2023)

Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells
por: Guarecuco, Rohiverth, et al.
Publicado: (2020)

Thiamine Metabolites and Dementia?
por: Kuller, Lewis H.
Publicado: (2015)

Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome
por: Siegmund, Stephanie E, et al.
Publicado: (2017)

Thiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells
por: Gangolf, Marjorie, et al.
Publicado: (2010)

The Effect of Thiamine and Thiamine Pyrophosphate on Oxidative Liver Damage Induced in Rats with Cisplatin
por: Turan, Mehmet Ibrahim, et al.
Publicado: (2013)

Thiamine deficiency in a cat: resolution of MRI abnormalities following thiamine supplementation
por: Palus, Viktor, et al.
Publicado: (2010)

Thiamine Deficiency in a Nondrinker and Secondary Pulmonary Edema after Thiamine Replenishment
por: Nakamura, Hiroyuki, et al.
Publicado: (2019)

A fresh look at thiamine deficiency—new analyses by the global thiamine alliance
por: Bourassa, Megan W., et al.
Publicado: (2021)

Thiamine Deficiency in a Patient With Schizophrenia: Precautions and Countermeasures for Subclinical Thiamine Deficiency
por: Ishida, Mayumi, et al.
Publicado: (2023)

A Novel Tetrapeptide Derivative Exhibits In Vitro Inhibition of Neutrophil-Derived Reactive Oxygen Species and Lysosomal Enzymes Release
por: Miriyala, Sumitra, et al.
Publicado: (2013)

The adaptive regulation of thiamine pyrophosphokinase-1 facilitates malignant growth during supplemental thiamine conditions
por: Jonus, Hunter C., et al.
Publicado: (2018)

Manganese Superoxide Dismutase: Guardian of the Powerhouse
por: Holley, Aaron K., et al.
Publicado: (2011)

GmPGL1, a Thiamine Thiazole Synthase, Is Required for the Biosynthesis of Thiamine in Soybean
por: Feng, Xingxing, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_qtmquh45q60llroeffivfiugc5