Targeting Arginine-Dependent Cancers with Arginine-Degrading Enzymes: Opportunities and Challenges

Arginine deprivation is a novel antimetabolite strategy for the treatment of arginine-dependent cancers that exploits differential expression and regulation of key urea cycle enzymes. Several studies have focused on inactivation of argininosuccinate synthetase 1 (ASS1) in a range of malignancies, in...

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Detalles Bibliográficos
Autores principales: Phillips, Melissa M., Sheaff, Michael T., Szlosarek, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893322/
https://www.ncbi.nlm.nih.gov/pubmed/24453997
http://dx.doi.org/10.4143/crt.2013.45.4.251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893322/
https://www.ncbi.nlm.nih.gov/pubmed/24453997
http://dx.doi.org/10.4143/crt.2013.45.4.251

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