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Targeting Arginine-Dependent Cancers with Arginine-Degrading Enzymes: Opportunities and Challenges
Arginine deprivation is a novel antimetabolite strategy for the treatment of arginine-dependent cancers that exploits differential expression and regulation of key urea cycle enzymes. Several studies have focused on inactivation of argininosuccinate synthetase 1 (ASS1) in a range of malignancies, in...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Korean Cancer Association
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893322/ https://www.ncbi.nlm.nih.gov/pubmed/24453997 http://dx.doi.org/10.4143/crt.2013.45.4.251 |