Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments

BACKGROUND: Tau is a microtubule stabilizing protein and is mainly expressed in neurons. Tau aggregation into oligomers and tangles is considered an important pathological event in tauopathies, such as frontotemporal dementia (FTD) and Alzheimer’s disease (AD). Tauopathies are also associated with d...

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Detalles Bibliográficos
Autores principales: Levenga, Josien, Krishnamurthy, Pavan, Rajamohamedsait, Hameetha, Wong, Helen, Franke, Thomas F, Cain, Peter, Sigurdsson, Einar M, Hoeffer, Charles A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893396/
https://www.ncbi.nlm.nih.gov/pubmed/24252661
http://dx.doi.org/10.1186/2051-5960-1-34

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