Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment

BACKGROUND: Protein aggregation and the formation of intracellular inclusions are a central feature of many neurodegenerative disorders, but precise knowledge about their pathogenic role is lacking in most instances. Here we have characterized inclusions formed in transgenic mice carrying the P56S m...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuijpers, Marijn, van Dis, Vera, Haasdijk, Elize D, Harterink, Martin, Vocking, Karin, Post, Jan A, Scheper, Wiep, Hoogenraad, Casper C, Jaarsma, Dick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893532/
https://www.ncbi.nlm.nih.gov/pubmed/24252306
http://dx.doi.org/10.1186/2051-5960-1-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893532/
https://www.ncbi.nlm.nih.gov/pubmed/24252306
http://dx.doi.org/10.1186/2051-5960-1-24

Ejemplares similares