Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer’s disease brain

BACKGROUND: Intracytoplasmic inclusions composed of filamentous tau proteins are defining characteristics of neurodegenerative tauopathies, but it remains unclear why different tau isoforms accumulate in different diseases and how they induce abnormal filamentous structures and pathologies. Two tau...

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Detalles Bibliográficos
Autores principales: Dan, Ayaho, Takahashi, Muneaki, Masuda-Suzukake, Masami, Kametani, Fuyuki, Nonaka, Takashi, Kondo, Hiromi, Akiyama, Haruhiko, Arai, Takao, Mann, David MA, Saito, Yuko, Hatsuta, Hiroyuki, Murayama, Shigeo, Hasegawa, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893535/
https://www.ncbi.nlm.nih.gov/pubmed/24252707
http://dx.doi.org/10.1186/2051-5960-1-54

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893535/
https://www.ncbi.nlm.nih.gov/pubmed/24252707
http://dx.doi.org/10.1186/2051-5960-1-54

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