Vitamin C induces Tet-dependent DNA demethylation in ESCs to promote a blastocyst-like state

DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and the suppression of retrotransposons(1). Global DNA demethylation occurs in the early embryo and the germline(2,3) and may be mediated by Tet (ten-eleven-translocation) enzymes(4–6), which convert 5-met...

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Detalles Bibliográficos
Autores principales: Blaschke, Kathryn, Ebata, Kevin T., Karimi, Mohammad M., Zepeda-Martínez, Jorge A., Goyal, Preeti, Mahapatra, Sahasransu, Tam, Angela, Laird, Diana J., Hirst, Martin, Rao, Anjana, Lorincz, Matthew C., Ramalho-Santos, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893718/
https://www.ncbi.nlm.nih.gov/pubmed/23812591
http://dx.doi.org/10.1038/nature12362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893718/
https://www.ncbi.nlm.nih.gov/pubmed/23812591
http://dx.doi.org/10.1038/nature12362

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