Computationally designed libraries for rapid enzyme stabilization

The ability to engineer enzymes and other proteins to any desired stability would have wide-ranging applications. Here, we demonstrate that computational design of a library with chemically diverse stabilizing mutations allows the engineering of drastically stabilized and fully functional variants o...

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Detalles Bibliográficos
Autores principales: Wijma, Hein J., Floor, Robert J., Jekel, Peter A., Baker, David, Marrink, Siewert J., Janssen, Dick B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893934/
https://www.ncbi.nlm.nih.gov/pubmed/24402331
http://dx.doi.org/10.1093/protein/gzt061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893934/
https://www.ncbi.nlm.nih.gov/pubmed/24402331
http://dx.doi.org/10.1093/protein/gzt061

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