Genomic Analysis of hESC Pedigrees Identifies De Novo Mutations and Enables Determination of the Timing and Origin of Mutational Events

Given the association between mutational load and cancer, the observation that genetic aberrations are frequently found in human pluripotent stem cells (hPSCs) is of concern. Prior studies in human induced pluripotent stem cells (hiPSCs) have shown that deletions and regions of loss of heterozygosit...

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Detalles Bibliográficos
Autores principales: Ben-Yosef, Dalit, Boscolo, Francesca S., Amir, Hadar, Malcov, Mira, Amit, Ami, Laurent, Louise C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894204/
https://www.ncbi.nlm.nih.gov/pubmed/24035391
http://dx.doi.org/10.1016/j.celrep.2013.08.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894204/
https://www.ncbi.nlm.nih.gov/pubmed/24035391
http://dx.doi.org/10.1016/j.celrep.2013.08.009

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