Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

Cyclic paroxysm and high fever are hallmarks of malaria and are associated with high levels of pyrogenic cytokines, including IL-1β. In this report, we describe a signature for the expression of inflammasome-related genes and caspase-1 activation in malaria. Indeed, when we infected mice, Plasmodium...

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Detalles Bibliográficos
Autores principales: Ataide, Marco A., Andrade, Warrison A., Zamboni, Dario S., Wang, Donghai, Souza, Maria do Carmo, Franklin, Bernardo S., Elian, Samir, Martins, Flaviano S., Pereira, Dhelio, Reed, George, Fitzgerald, Katherine A., Golenbock, Douglas T., Gazzinelli, Ricardo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894209/
https://www.ncbi.nlm.nih.gov/pubmed/24453977
http://dx.doi.org/10.1371/journal.ppat.1003885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894209/
https://www.ncbi.nlm.nih.gov/pubmed/24453977
http://dx.doi.org/10.1371/journal.ppat.1003885

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