Alphavirus Mutator Variants Present Host-Specific Defects and Attenuation in Mammalian and Insect Models

Arboviruses cycle through both vertebrates and invertebrates, which requires them to adapt to disparate hosts while maintaining genetic integrity during genome replication. To study the genetic mechanisms and determinants of these processes, we use chikungunya virus (CHIKV), a re-emerging human path...

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Detalles Bibliográficos
Autores principales: Rozen-Gagnon, Kathryn, Stapleford, Kenneth A., Mongelli, Vanesa, Blanc, Hervé, Failloux, Anna-Bella, Saleh, Maria-Carla, Vignuzzi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894214/
https://www.ncbi.nlm.nih.gov/pubmed/24453971
http://dx.doi.org/10.1371/journal.ppat.1003877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894214/
https://www.ncbi.nlm.nih.gov/pubmed/24453971
http://dx.doi.org/10.1371/journal.ppat.1003877

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