HIV Protective KIR3DL1/S1-HLA-B Genotypes Influence NK Cell-Mediated Inhibition of HIV Replication in Autologous CD4 Targets

Carriage of the genetic combination encoding a high expression inhibitory Killer Immunoglobulin-like Receptor (KIR)3DL1 with its ligand, HLA-B*57 (*h/*y+B*57) is associated with slower time to AIDS and better HIV viral load control than being a Bw6 homozygote (Bw6hmz). Natural Killer (NK) cells from...

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Detalles Bibliográficos
Autores principales: Song, Rujun, Lisovsky, Irene, Lebouché, Bertrand, Routy, Jean-Pierre, Bruneau, Julie, Bernard, Nicole F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894215/
https://www.ncbi.nlm.nih.gov/pubmed/24453969
http://dx.doi.org/10.1371/journal.ppat.1003867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894215/
https://www.ncbi.nlm.nih.gov/pubmed/24453969
http://dx.doi.org/10.1371/journal.ppat.1003867

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