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Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences

The sodium/bicarbonate cotransporter (NBC) is one of the major alkalinizing mechanisms in the cardiomyocytes. It has been demonstrated the existence of at least two functional isoforms, one that promotes the co-influx of 1 molecule of Na(+) per 1 molecule of HCO(−)(3) (electroneutral isoform; NBCn1)...

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Detalles Bibliográficos
Autores principales: De Giusti, Verónica C., Ciancio, María C., Orlowski, Alejandro, Aiello, Ernesto A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894460/
https://www.ncbi.nlm.nih.gov/pubmed/24478712
http://dx.doi.org/10.3389/fphys.2013.00411