Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice

Human ApoE4 accelerates memory decline in ageing and in Alzheimer's disease. Although intranasal insulin can improve cognition, this has little effect in ApoE4 subjects. To understand this ApoE genotype-dependent effect, we examined brain insulin signaling in huApoE3 and huApoE4 targeted replac...

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Detalles Bibliográficos
Autores principales: Ong, Qi-Rui, Chan, Elizabeth S., Lim, Mei-Li, Cole, Gregory M., Wong, Boon-Seng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894554/
https://www.ncbi.nlm.nih.gov/pubmed/24435134
http://dx.doi.org/10.1038/srep03754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894554/
https://www.ncbi.nlm.nih.gov/pubmed/24435134
http://dx.doi.org/10.1038/srep03754

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