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Imatinib in Chronic Myeloid Leukemia: an Overview

Imatinib was the first signal transduction inhibitor (STI), used in a clinical setting. It prevents a BCR-ABL protein from exerting its role in the oncogenic pathway in chronic myeloid leukemia (CML). Imatinib directly inhibits the constitutive tyrosine kinase activity. Imatinib binds to BCR-ABL kin...

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Detalles Bibliográficos
Autor principal: Sacha, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894842/
https://www.ncbi.nlm.nih.gov/pubmed/24455116
http://dx.doi.org/10.4084/MJHID.2014.007