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The Not4 E3 Ligase and CCR4 Deadenylase Play Distinct Roles in Protein Quality Control
Eukaryotic cells control their proteome by regulating protein production and protein clearance. Protein production is determined to a large extent by mRNA levels, whereas protein degradation depends mostly upon the proteasome. Dysfunction of the proteasome leads to the accumulation of non-functional...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895043/ https://www.ncbi.nlm.nih.gov/pubmed/24465968 http://dx.doi.org/10.1371/journal.pone.0086218 |