A new regulatory pathway of mRNA export by an F-box protein, Mdm30

Mdm30, an F-box protein in yeast, has been recently shown to promote mRNA export. However, it remains unknown how Mdm30 facilitates mRNA export. Here, we show that Mdm30 targets the Sub2 component of the TREX (Transcription/Export) complex for ubiquitylation and subsequent proteasomal degradation. S...

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Detalles Bibliográficos
Autores principales: Durairaj, Geetha, Lahudkar, Shweta, Bhaumik, Sukesh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895266/
https://www.ncbi.nlm.nih.gov/pubmed/24327750
http://dx.doi.org/10.1261/rna.042325.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895266/
https://www.ncbi.nlm.nih.gov/pubmed/24327750
http://dx.doi.org/10.1261/rna.042325.113

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