Tissue-specific gene silencing monitored in circulating RNA

Pharmacologic target gene modulation is the primary objective for RNA antagonist strategies and gene therapy. Here we show that mRNAs encoding tissue-specific gene transcripts can be detected in biological fluids and that RNAi-mediated target gene silencing in the liver and brain results in quantita...

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Detalles Bibliográficos
Autores principales: Sehgal, Alfica, Chen, Qingmin, Gibbings, Derrick, Sah, Dinah W.Y., Bumcrot, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895267/
https://www.ncbi.nlm.nih.gov/pubmed/24355758
http://dx.doi.org/10.1261/rna.042507.113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895267/
https://www.ncbi.nlm.nih.gov/pubmed/24355758
http://dx.doi.org/10.1261/rna.042507.113

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