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Variola virus E3L Zα domain, but not its Z-DNA binding activity, is required for PKR inhibition
Responding to viral infection, the interferon-induced, double-stranded RNA (dsRNA)–activated protein kinase PKR phosphorylates translation initiation factor eIF2α to inhibit cellular and viral protein synthesis. To overcome this host defense mechanism, many poxviruses express the protein E3L, contai...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895273/ https://www.ncbi.nlm.nih.gov/pubmed/24335187 http://dx.doi.org/10.1261/rna.042341.113 |