Structure-guided discovery of carboxy-SAM as a novel metabolite modulating tRNA function

Identifying novel metabolites and characterizing their biological functions are major challenges of the post-genomic era. X-ray crystallography can reveal unanticipated ligands which persist through purification and crystallization. These adventitious protein:ligand complexes provide insights into n...

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Detalles Bibliográficos
Autores principales: Kim, Jungwook, Xiao, Hui, Bonanno, Jeffrey B., Kalyanaraman, Chakrapani, Brown, Shoshana, Tang, Xiangying, Al-Obaidi, Nawar F., Patskovsky, Yury, Babbitt, Patricia C., Jacobson, Matthew P., Lee, Young-Sam, Almo, Steven C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895326/
https://www.ncbi.nlm.nih.gov/pubmed/23676670
http://dx.doi.org/10.1038/nature12180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895326/
https://www.ncbi.nlm.nih.gov/pubmed/23676670
http://dx.doi.org/10.1038/nature12180

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