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Structure-guided discovery of carboxy-SAM as a novel metabolite modulating tRNA function
Identifying novel metabolites and characterizing their biological functions are major challenges of the post-genomic era. X-ray crystallography can reveal unanticipated ligands which persist through purification and crystallization. These adventitious protein:ligand complexes provide insights into n...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895326/ https://www.ncbi.nlm.nih.gov/pubmed/23676670 http://dx.doi.org/10.1038/nature12180 |