Adenosine is required for sustained inflammasome activation via the A(2A) receptor and the HIF-1α pathway

Inflammasome pathways are important in chronic diseases, but it is not known how the signalling is sustained after initiation. Inflammasome activation is dependent on stimuli such as LPS and ATP that provide two distinct signals resulting in rapid production of IL-1β, with lack of response to repeat...

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Detalles Bibliográficos
Autores principales: Ouyang, Xinshou, Ghani, Ayaz, Malik, Ahsan, Wilder, Tuere, Colegio, Oscar, Flavell, Richard Anthony, Cronstein, Bruce Neil, Mehal, Wajahat Zafar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895487/
https://www.ncbi.nlm.nih.gov/pubmed/24352507
http://dx.doi.org/10.1038/ncomms3909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895487/
https://www.ncbi.nlm.nih.gov/pubmed/24352507
http://dx.doi.org/10.1038/ncomms3909

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