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Adenosine is required for sustained inflammasome activation via the A(2A) receptor and the HIF-1α pathway
Inflammasome pathways are important in chronic diseases, but it is not known how the signalling is sustained after initiation. Inflammasome activation is dependent on stimuli such as LPS and ATP that provide two distinct signals resulting in rapid production of IL-1β, with lack of response to repeat...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895487/ https://www.ncbi.nlm.nih.gov/pubmed/24352507 http://dx.doi.org/10.1038/ncomms3909 |