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Fast selection of miRNA candidates based on large-scale pre-computed MFE sets of randomized sequences
BACKGROUND: Small RNAs are important regulators of genome function, yet their prediction in genomes is still a major computational challenge. Statistical analyses of pre-miRNA sequences indicated that their 2D structure tends to have a minimal free energy (MFE) significantly lower than MFE values of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895842/ https://www.ncbi.nlm.nih.gov/pubmed/24418292 http://dx.doi.org/10.1186/1756-0500-7-34 |