HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells

BACKGROUND: Hypoxia is a major driving force in vascularization and vascular remodeling. Pharmacological inhibition of prolyl hydroxylases (PHDs) leads to an oxygen-independent and long-lasting activation of hypoxia-inducible factors (HIFs). Whereas effects of HIF-stabilization on transcriptional re...

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Detalles Bibliográficos
Autores principales: Weidemann, Alexander, Breyer, Johannes, Rehm, Margot, Eckardt, Kai-Uwe, Daniel, Christoph, Cicha, Iwona, Giehl, Klaudia, Goppelt-Struebe, Margarete
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895861/
https://www.ncbi.nlm.nih.gov/pubmed/24144209
http://dx.doi.org/10.1186/1478-811X-11-80

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895861/
https://www.ncbi.nlm.nih.gov/pubmed/24144209
http://dx.doi.org/10.1186/1478-811X-11-80

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