The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

We show that the splicing regulator PTBP2 controls a genetic program essential for neuronal maturation. Depletion of PTBP2 in developing mouse cortex leads to degeneration of these tissues over the first three postnatal weeks, a time when the normal cortex expands and develops mature circuits. Cultu...

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Detalles Bibliográficos
Autores principales: Li, Qin, Zheng, Sika, Han, Areum, Lin, Chia-Ho, Stoilov, Peter, Fu, Xiang-Dong, Black, Douglas L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896118/
https://www.ncbi.nlm.nih.gov/pubmed/24448406
http://dx.doi.org/10.7554/eLife.01201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896118/
https://www.ncbi.nlm.nih.gov/pubmed/24448406
http://dx.doi.org/10.7554/eLife.01201

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