Cargando…

The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

We show that the splicing regulator PTBP2 controls a genetic program essential for neuronal maturation. Depletion of PTBP2 in developing mouse cortex leads to degeneration of these tissues over the first three postnatal weeks, a time when the normal cortex expands and develops mature circuits. Cultu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Qin, Zheng, Sika, Han, Areum, Lin, Chia-Ho, Stoilov, Peter, Fu, Xiang-Dong, Black, Douglas L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Genes and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896118/ https://www.ncbi.nlm.nih.gov/pubmed/24448406 http://dx.doi.org/10.7554/eLife.01201

Ejemplares similares

Correction: The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation
por: Li, Qin, et al.
Publicado: (2017)

De Novo Prediction of PTBP1 Binding and Splicing Targets Reveals Unexpected Features of Its RNA Recognition and Function
por: Han, Areum, et al.
Publicado: (2014)

Striking circadian neuron diversity and cycling of Drosophila alternative splicing
por: Wang, Qingqing, et al.
Publicado: (2018)

Maturation of selected human mitochondrial tRNAs requires deadenylation
por: Pearce, Sarah F, et al.
Publicado: (2017)

Exon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in Drosophila melanogaster
por: Choudhury, Subhendu Roy, et al.
Publicado: (2016)

Alternative splicing of apoptosis genes promotes human T cell survival
por: Blake, Davia, et al.
Publicado: (2022)

Coverage-dependent bias creates the appearance of binary splicing in single cells
por: Buen Abad Najar, Carlos F, et al.
Publicado: (2020)

Viral-induced alternative splicing of host genes promotes influenza replication
por: Thompson, Matthew G, et al.
Publicado: (2020)

SAM homeostasis is regulated by CFI(m)-mediated splicing of MAT2A
por: Scarborough, Anna M, et al.
Publicado: (2021)

Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer
por: Munkley, Jennifer, et al.
Publicado: (2019)

Robust and annotation-free analysis of alternative splicing across diverse cell types in mice
por: Benegas, Gonzalo, et al.
Publicado: (2022)

SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX
por: Wagner, Allison R, et al.
Publicado: (2022)

RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit
por: Milligan, Laura, et al.
Publicado: (2017)

The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals
por: Stagsted, Lotte Victoria Winther, et al.
Publicado: (2021)

Non-canonical TAF complexes regulate active promoters in human embryonic stem cells
por: Maston, Glenn A, et al.
Publicado: (2012)

An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning
por: Ehrmann, Ingrid, et al.
Publicado: (2019)

Multiple decay events target HAC1 mRNA during splicing to regulate the unfolded protein response
por: Cherry, Patrick D, et al.
Publicado: (2019)

The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation
por: Linares, Anthony J, et al.
Publicado: (2015)

Multiple determinants of splicing repression activity in the polypyrimidine tract binding proteins, PTBP1 and PTBP2
por: Keppetipola, Niroshika M., et al.
Publicado: (2016)

Identification of RBPMS as a mammalian smooth muscle master splicing regulator via proximity of its gene with super-enhancers
por: Nakagaki-Silva, Erick E, et al.
Publicado: (2019)

Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment
por: Han, Brenda Y, et al.
Publicado: (2014)

Natural antisense transcripts regulate the neuronal stress response and excitability
por: Zheng, Xingguo, et al.
Publicado: (2014)

m(6)A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site
por: Parker, Matthew T, et al.
Publicado: (2022)

Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse
por: Isbel, Luke, et al.
Publicado: (2016)

A receptor and neuron that activate a circuit limiting sucrose consumption
por: Joseph, Ryan M, et al.
Publicado: (2017)

Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo
por: Petrenko, Natalia, et al.
Publicado: (2017)

Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons
por: Monahan, Kevin, et al.
Publicado: (2017)

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint
por: Carvalho, Sílvia, et al.
Publicado: (2014)

Developmental programming modulates olfactory behavior in C. elegans via endogenous RNAi pathways
por: Sims, Jennie R, et al.
Publicado: (2016)

The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart
por: Taliani, Valeria, et al.
Publicado: (2023)

Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation
por: Yeo, Shi Yun, et al.
Publicado: (2016)

Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells
por: Hogan, Nicholas T, et al.
Publicado: (2017)

MALAT1 modulates alternative splicing by cooperating with the splicing factors PTBP1 and PSF
por: Miao, Hui, et al.
Publicado: (2022)

Bidirectional regulation of postmitotic H3K27me3 distributions underlie cerebellar granule neuron maturation dynamics
por: Ramesh, Vijyendra, et al.
Publicado: (2023)

RNase H enables efficient repair of R-loop induced DNA damage
por: Amon, Jeremy D, et al.
Publicado: (2016)

One genome’s junk is another’s garbage
por: Bright, Lydia J, et al.
Publicado: (2016)

The homologous recombination machinery modulates the formation of RNA–DNA hybrids and associated chromosome instability
por: Wahba, Lamia, et al.
Publicado: (2013)

PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes
por: Zhu, Binglin, et al.
Publicado: (2023)

Crosstalk within a functional INO80 complex dimer regulates nucleosome sliding
por: Willhoft, Oliver, et al.
Publicado: (2017)

Chromosome-specific maturation of the epigenome in the Drosophila male germline
por: Anderson, James T, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_aupb4hnf6vjr0146lu52c54sgt