One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions

The consecutive radical/ionic reaction consisting of radical formylation of alkyl bromides and nucleophilic addition of a cyanide ion was investigated, which gave moderate to good yields of cyanohydrin derivatives in one-pot.

Detalles Bibliográficos
Autores principales: Sumino, Shuhei, Fusano, Akira, Okai, Hiroyuki, Fukuyama, Takahide, Ryu, Ilhyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896227/
https://www.ncbi.nlm.nih.gov/pubmed/24454568
http://dx.doi.org/10.3762/bjoc.10.12
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author Sumino, Shuhei
Fusano, Akira
Okai, Hiroyuki
Fukuyama, Takahide
Ryu, Ilhyong
author_facet Sumino, Shuhei
Fusano, Akira
Okai, Hiroyuki
Fukuyama, Takahide
Ryu, Ilhyong
author_sort Sumino, Shuhei
collection PubMed
description The consecutive radical/ionic reaction consisting of radical formylation of alkyl bromides and nucleophilic addition of a cyanide ion was investigated, which gave moderate to good yields of cyanohydrin derivatives in one-pot.
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spelling pubmed-38962272014-01-21 One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions Sumino, Shuhei Fusano, Akira Okai, Hiroyuki Fukuyama, Takahide Ryu, Ilhyong Beilstein J Org Chem Letter The consecutive radical/ionic reaction consisting of radical formylation of alkyl bromides and nucleophilic addition of a cyanide ion was investigated, which gave moderate to good yields of cyanohydrin derivatives in one-pot. Beilstein-Institut 2014-01-14 /pmc/articles/PMC3896227/ /pubmed/24454568 http://dx.doi.org/10.3762/bjoc.10.12 Text en Copyright © 2014, Sumino et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Sumino, Shuhei
Fusano, Akira
Okai, Hiroyuki
Fukuyama, Takahide
Ryu, Ilhyong
One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions
title One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions
title_full One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions
title_fullStr One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions
title_full_unstemmed One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions
title_short One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions
title_sort one-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896227/
https://www.ncbi.nlm.nih.gov/pubmed/24454568
http://dx.doi.org/10.3762/bjoc.10.12
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