Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1–DNA-complex formation

Hedgehog (Hh) signaling plays an important role in embryonic development, cell maintenance and cell proliferation. Moreover, Hh signaling contributes to the growth of cancer cells. Physalins are highly oxidized natural products with a complex structure. Physalins (1–7) were isolated from Solanum nig...

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Detalles Bibliográficos
Autores principales: Arai, Midori A, Uchida, Kyoko, Sadhu, Samir K, Ahmed, Firoj, Ishibashi, Masami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896228/
https://www.ncbi.nlm.nih.gov/pubmed/24454566
http://dx.doi.org/10.3762/bjoc.10.10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896228/
https://www.ncbi.nlm.nih.gov/pubmed/24454566
http://dx.doi.org/10.3762/bjoc.10.10

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