Interleukin-4-Mediated 15-Lipoxygenase-1 Trans-Activation Requires UTX Recruitment and H3K27me3 Demethylation at the Promoter in A549 Cells

Arachidonate 15-lipoxygenase-1 (ALOX15) oxygenates polyunsaturated fatty acids and bio-membranes, generating multiple lipid signalling mediators involved in inflammation. Several lines of evidence indicate that ALOX15 activation in the respiratory tract contributes to asthma progression. Recent expe...

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Detalles Bibliográficos
Autores principales: Han, Hongya, Xu, Dawei, Liu, Cheng, Claesson, Hans-Erik, Björkholm, Magnus, Sjöberg, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896354/
https://www.ncbi.nlm.nih.gov/pubmed/24465480
http://dx.doi.org/10.1371/journal.pone.0085085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896354/
https://www.ncbi.nlm.nih.gov/pubmed/24465480
http://dx.doi.org/10.1371/journal.pone.0085085

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