A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction

Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/paraganglioma tumors. Several mechanisms have been proposed to account for Sdh-mutation-induced tumorigenesis, the most accepted of which is based on the constitutive expression of the hy...

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Detalles Bibliográficos
Autores principales: Millán-Uclés, África, Díaz-Castro, Blanca, García-Flores, Paula, Báez, Alicia, Pérez-Simón, José Antonio, López-Barneo, José, Piruat, José I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896393/
https://www.ncbi.nlm.nih.gov/pubmed/24465590
http://dx.doi.org/10.1371/journal.pone.0085528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896393/
https://www.ncbi.nlm.nih.gov/pubmed/24465590
http://dx.doi.org/10.1371/journal.pone.0085528

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