Chronic Treatment with Novel Small Molecule Hsp90 Inhibitors Rescues Striatal Dopamine Levels but Not α-Synuclein-Induced Neuronal Cell Loss

Hsp90 inhibitors such as geldanamycin potently induce Hsp70 and reduce cytotoxicity due to α-synuclein expression, although their use has been limited due to toxicity, brain permeability, and drug design. We recently described the effects of a novel class of potent, small molecule Hsp90 inhibitors i...

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Detalles Bibliográficos
Autores principales: McFarland, Nikolaus R., Dimant, Hemi, Kibuuka, Laura, Ebrahimi-Fakhari, Darius, Desjardins, Cody A., Danzer, Karin M., Danzer, Michael, Fan, Zhanyun, Schwarzschild, Michael A., Hirst, Warren, McLean, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896461/
https://www.ncbi.nlm.nih.gov/pubmed/24465863
http://dx.doi.org/10.1371/journal.pone.0086048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896461/
https://www.ncbi.nlm.nih.gov/pubmed/24465863
http://dx.doi.org/10.1371/journal.pone.0086048

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