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Structure-Function Analysis of the C-clamp of TCF/Pangolin in Wnt/ß-catenin Signaling

The evolutionarily conserved Wnt/ß-catenin (Wnt/ß-cat) pathway plays an important role in animal development in metazoans. Many Wnt targets are regulated by members of the TCF/LEF1 (TCF) family of transcription factors. All TCFs contain a High Mobility Group (HMG) domain that bind specific DNA seque...

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Detalles Bibliográficos
Autores principales: Ravindranath, Aditi, Cadigan, Ken M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896468/
https://www.ncbi.nlm.nih.gov/pubmed/24465946
http://dx.doi.org/10.1371/journal.pone.0086180