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Complex Regulation of PKCβ2 and PDK-1/AKT by ROCK2 in Diabetic Heart

OBJECTIVES: The RhoA/ROCK pathway contributes to diabetic cardiomyopathy in part by promoting the sustained activation of PKCβ2 but the details of their interaction are unclear. The purpose of this study was to investigate if over-activation of ROCK in the diabetic heart leads to direct phosphorylat...

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Detalles Bibliográficos
Autores principales: Lin, Guorong, Brownsey, Roger W., MacLeod, Kathleen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896488/
https://www.ncbi.nlm.nih.gov/pubmed/24466133
http://dx.doi.org/10.1371/journal.pone.0086520