Natural and glucosyl flavonoids inhibit poly(ADP-ribose) polymerase activity and induce synthetic lethality in BRCA mutant cells

Poly(ADP-ribose) polymerase (PARP) inhibitors have been proven to represent superior clinical agents targeting DNA repair mechanisms in cancer therapy. We investigated PARP inhibitory effects of the natural and synthetic flavonoids (quercetin, rutin, monoglucosyl rutin and maltooligosyl rutin) and t...

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Detalles Bibliográficos
Autores principales: MAEDA, JUNKO, ROYBAL, ERICA J., BRENTS, COLLEEN A., UESAKA, MITSURU, AIZAWA, YASUSHI, KATO, TAKAMITSU A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896521/
https://www.ncbi.nlm.nih.gov/pubmed/24317580
http://dx.doi.org/10.3892/or.2013.2902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896521/
https://www.ncbi.nlm.nih.gov/pubmed/24317580
http://dx.doi.org/10.3892/or.2013.2902

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