Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons

BACKGROUND: Several lines of evidence suggest that CCL2 could initiate the hyperalgesia of neuropathic pain by causing central sensitization of spinal dorsal horn neurons and facilitating nociceptive transmission in the spinal dorsal horn. The cellular and molecular mechanisms by which CCL2 enhances...

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Detalles Bibliográficos
Autores principales: Huang, Chung-Yu, Chen, Ying-Ling, Li, Allen H, Lu, Juu-Chin, Wang, Hung-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896825/
https://www.ncbi.nlm.nih.gov/pubmed/24405660
http://dx.doi.org/10.1186/1742-2094-11-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896825/
https://www.ncbi.nlm.nih.gov/pubmed/24405660
http://dx.doi.org/10.1186/1742-2094-11-7

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