p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition

Proteasome inhibition elicits an evolutionarily conserved response wherein proteasome subunit mRNAs are upregulated, resulting in recovery (i.e., ‘bounce-back’) of proteasome activity. We previously demonstrated that the transcription factor Nrf1/NFE2L1 mediates this homeostatic response in mammalia...

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Detalles Bibliográficos
Autores principales: Radhakrishnan, Senthil K, den Besten, Willem, Deshaies, Raymond J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896944/
https://www.ncbi.nlm.nih.gov/pubmed/24448410
http://dx.doi.org/10.7554/eLife.01856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896944/
https://www.ncbi.nlm.nih.gov/pubmed/24448410
http://dx.doi.org/10.7554/eLife.01856

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