Genome maintenance in pluripotent stem cells

Pluripotent stem cells (PSCs) must maintain their proper genomic content in order to preserve appropriate self-renewal and differentiation capacities. However, their prolonged in vitro propagation, as well as the environmental culture conditions, present serious challenges to genome maintenance. Rec...

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Detalles Bibliográficos
Autores principales: Weissbein, Uri, Benvenisty, Nissim, Ben-David, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897183/
https://www.ncbi.nlm.nih.gov/pubmed/24446481
http://dx.doi.org/10.1083/jcb.201310135
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author Weissbein, Uri
Benvenisty, Nissim
Ben-David, Uri
author_facet Weissbein, Uri
Benvenisty, Nissim
Ben-David, Uri
author_sort Weissbein, Uri
collection PubMed
description Pluripotent stem cells (PSCs) must maintain their proper genomic content in order to preserve appropriate self-renewal and differentiation capacities. However, their prolonged in vitro propagation, as well as the environmental culture conditions, present serious challenges to genome maintenance. Recent work has been focused on potential means to alleviate the genomic insults experienced by PSCs, and to detect them as soon as they arise, in order to prevent the detrimental consequences of these genomic aberrations on PSC application in basic research and regenerative medicine.
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spelling pubmed-38971832014-07-20 Genome maintenance in pluripotent stem cells Weissbein, Uri Benvenisty, Nissim Ben-David, Uri J Cell Biol Reviews Pluripotent stem cells (PSCs) must maintain their proper genomic content in order to preserve appropriate self-renewal and differentiation capacities. However, their prolonged in vitro propagation, as well as the environmental culture conditions, present serious challenges to genome maintenance. Recent work has been focused on potential means to alleviate the genomic insults experienced by PSCs, and to detect them as soon as they arise, in order to prevent the detrimental consequences of these genomic aberrations on PSC application in basic research and regenerative medicine. The Rockefeller University Press 2014-01-20 /pmc/articles/PMC3897183/ /pubmed/24446481 http://dx.doi.org/10.1083/jcb.201310135 Text en © 2014 Weissbein et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Weissbein, Uri
Benvenisty, Nissim
Ben-David, Uri
Genome maintenance in pluripotent stem cells
title Genome maintenance in pluripotent stem cells
title_full Genome maintenance in pluripotent stem cells
title_fullStr Genome maintenance in pluripotent stem cells
title_full_unstemmed Genome maintenance in pluripotent stem cells
title_short Genome maintenance in pluripotent stem cells
title_sort genome maintenance in pluripotent stem cells
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897183/
https://www.ncbi.nlm.nih.gov/pubmed/24446481
http://dx.doi.org/10.1083/jcb.201310135
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