A Substrate Radical Intermediate in Catalysis by the Antibiotic Resistance Protein Cfr

Cfr-dependent methylation of C8 of adenosine 2503 (A2503) in 23S rRNA confers bacterial resistance to an array of clinically important antibiotics that target the large subunit of the ribosome, including the synthetic oxazolidinone antibiotic linezolid. The key element of the proposed mechanism for...

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Detalles Bibliográficos
Autores principales: Grove, Tyler L., Livada, Jovan, Schwalm, Erica L., Green, Michael T., Booker, Squire J., Silakov, Alexey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897224/
https://www.ncbi.nlm.nih.gov/pubmed/23644479
http://dx.doi.org/10.1038/nchembio.1251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897224/
https://www.ncbi.nlm.nih.gov/pubmed/23644479
http://dx.doi.org/10.1038/nchembio.1251

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