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A Substrate Radical Intermediate in Catalysis by the Antibiotic Resistance Protein Cfr
Cfr-dependent methylation of C8 of adenosine 2503 (A2503) in 23S rRNA confers bacterial resistance to an array of clinically important antibiotics that target the large subunit of the ribosome, including the synthetic oxazolidinone antibiotic linezolid. The key element of the proposed mechanism for...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897224/ https://www.ncbi.nlm.nih.gov/pubmed/23644479 http://dx.doi.org/10.1038/nchembio.1251 |