Innate Functions of Immunoglobulin M Lessen Liver Gene Transfer with Helper-Dependent Adenovirus

The immune system poses obstacles to viral vectors, even in the first administration to preimmunized hosts. We have observed that the livers of B cell-deficient mice were more effectively transduced by a helper-dependent adenovirus serotype-5 (HDA) vector than those of WT mice. This effect was T-cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Unzu, Carmen, Melero, Ignacio, Morales-Kastresana, Aizea, Sampedro, Ana, Serrano-Mendioroz, Irantzu, Azpilikueta, Arantza, Ochoa, María Carmen, Dubrot, Juan, Martínez-Ansó, Eduardo, Fontanellas, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897443/
https://www.ncbi.nlm.nih.gov/pubmed/24465560
http://dx.doi.org/10.1371/journal.pone.0085432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897443/
https://www.ncbi.nlm.nih.gov/pubmed/24465560
http://dx.doi.org/10.1371/journal.pone.0085432

Ejemplares similares