LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct Pathways

The LMO2 oncogene is deregulated in the majority of human T-cell leukemia cases and in most gene therapy-induced T-cell leukemias. We made transgenic mice with enforced expression of Lmo2 in T-cells by the CD2 promoter/enhancer. These transgenic mice developed highly penetrant T-ALL by two distinct...

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Detalles Bibliográficos
Autores principales: Smith, Stephen, Tripathi, Rati, Goodings, Charnise, Cleveland, Susan, Mathias, Elizabeth, Hardaway, J. Andrew, Elliott, Natalina, Yi, Yajun, Chen, Xi, Downing, James, Mullighan, Charles, Swing, Deborah A., Tessarollo, Lino, Li, Liqi, Love, Paul, Jenkins, Nancy A., Copeland, Neal G., Thompson, Mary Ann, Du, Yang, Davé, Utpal P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897537/
https://www.ncbi.nlm.nih.gov/pubmed/24465765
http://dx.doi.org/10.1371/journal.pone.0085883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897537/
https://www.ncbi.nlm.nih.gov/pubmed/24465765
http://dx.doi.org/10.1371/journal.pone.0085883

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