Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road

Effector T cells become rapidly inactivated after antigen exposure due to extracellular as well as intrinsic signals. We have recently demonstrated that the deletion of diacylglycerol kinases, intrinsic inhibitors of T-cell signaling, enhances the activity of adoptively transferred T cells expressin...

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Detalles Bibliográficos
Autores principales: Wang, Liang-Chuan S, Riese, Matthew J, Moon, Edmund K, Albelda, Steven M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897565/
https://www.ncbi.nlm.nih.gov/pubmed/24490126
http://dx.doi.org/10.4161/onci.26492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897565/
https://www.ncbi.nlm.nih.gov/pubmed/24490126
http://dx.doi.org/10.4161/onci.26492

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