Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road

Effector T cells become rapidly inactivated after antigen exposure due to extracellular as well as intrinsic signals. We have recently demonstrated that the deletion of diacylglycerol kinases, intrinsic inhibitors of T-cell signaling, enhances the activity of adoptively transferred T cells expressin...

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Detalles Bibliográficos
Autores principales: Wang, Liang-Chuan S, Riese, Matthew J, Moon, Edmund K, Albelda, Steven M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897565/
https://www.ncbi.nlm.nih.gov/pubmed/24490126
http://dx.doi.org/10.4161/onci.26492
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author Wang, Liang-Chuan S
Riese, Matthew J
Moon, Edmund K
Albelda, Steven M
author_facet Wang, Liang-Chuan S
Riese, Matthew J
Moon, Edmund K
Albelda, Steven M
author_sort Wang, Liang-Chuan S
collection PubMed
description Effector T cells become rapidly inactivated after antigen exposure due to extracellular as well as intrinsic signals. We have recently demonstrated that the deletion of diacylglycerol kinases, intrinsic inhibitors of T-cell signaling, enhances the activity of adoptively transferred T cells expressing a chimeric antigen receptor (CAR) specific for a tumor-associated antigen.
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spelling pubmed-38975652014-01-31 Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road Wang, Liang-Chuan S Riese, Matthew J Moon, Edmund K Albelda, Steven M Oncoimmunology Author's View Effector T cells become rapidly inactivated after antigen exposure due to extracellular as well as intrinsic signals. We have recently demonstrated that the deletion of diacylglycerol kinases, intrinsic inhibitors of T-cell signaling, enhances the activity of adoptively transferred T cells expressing a chimeric antigen receptor (CAR) specific for a tumor-associated antigen. Landes Bioscience 2013-11-01 2013-10-10 /pmc/articles/PMC3897565/ /pubmed/24490126 http://dx.doi.org/10.4161/onci.26492 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Wang, Liang-Chuan S
Riese, Matthew J
Moon, Edmund K
Albelda, Steven M
Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road
title Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road
title_full Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road
title_fullStr Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road
title_full_unstemmed Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road
title_short Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road
title_sort overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred t cells: re-tuning your car before hitting a rocky road
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897565/
https://www.ncbi.nlm.nih.gov/pubmed/24490126
http://dx.doi.org/10.4161/onci.26492
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